We kept the historical definition of hypertension (≥140/90 mm Hg) and also adjusted for actual blood pressure values, considering the paramount importance of hypertension as a stroke risk factor. In 2017, the American College of Cardiology/American Heart Association guideline lowered the threshold for the definition of hypertension in adults (≥130/80 mm Hg). The combined analysis of these two subtypes of ischaemic stroke is suboptimal and did not discriminate between these two types of TS. Thrombotic stroke (TS) included non-embolic and arterial embolic stroke (ES). While the statistical power for ischaemic stroke was adequate, there were fewer intracerebral haemorrhage events, which challenged a fair comparison of models for ischaemic and haemorrhagic stroke events. This large prospective cohort with long-term follow-up and well-adjudicated stroke events provided sufficient statistical power for rigorous adjustment.
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